This review summarizes a range of intervention strategies designed to wake up cardiac regeneration and promote myocardial repair in the setting of residual following myocardial injury, and discusses the translational progress of these strategies.
Myocardial infarction (MI) remains a leading cause of death worldwide, and therapies that limit injury, promote repair, and restore cardiac function remain limited. Human induced pluripotent stem cells (hiPSCs) provide a renewable source of patient-specific cardiac cells and have enabled the development of increasingly...
Benjamin B. Johnson, C. Mummery, Richard P. Davis· Cell Reports Medicine· 0 citations
This review evaluates recent developments in hiPSC technology, beginning with the generation of patient-specific models of inherited arrhythmias and cardiomyopathies, and examines progress in directing hiPSCs into specialized lineages, including cardiomyocytes, pacemaker cells, and Purkinje fibers.
Berra Koskulu, Tabish Ali, Ilkin Tetik-Altintop et al.· Journal of the American Hear...· 0 citations
This review systematically analyzes the key issues facing EV-based therapeutic strategies in their progression from experimental research to clinical application, providing a practical theoretical framework for EV-based myocardial repair therapies and clarifying the prospects for EVs in the treatment of MI.
Kaiyi Zhu, Jing Bai, Liang-Fu Xu et al.· Journal of Controlled Releas...· 0 citations
Cardiac fibrosis is a central pathological hallmark of diverse cardiovascular disorders, driving myocardial stiffening, ventricular dysfunction, and the progression of heart failure. Following cardiac injury, resident quiescent fibroblasts activate into pro‑fibrotic myofibroblasts, which overproduce extracellular matri...
Na Zhang, Xiao-Ming Feng, Wen-Chong Zou· Ageing Research Reviews· 0 citations
Ischemic heart disease is the leading cause of global morbidity and mortality. The immune system plays a pivotal role in the physiological and pathological processes within the cardiovascular system. The dysregulated inflammatory microenvironment in the heart can severely prevent infarcted cardiac repair by matrix degr...
Muhammad Rafique, Muhammad Umer Khan Niazi, Onaza Ali et al.· Med-X· 0 citations
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