Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...
Xin Gao, An-Yi Wu, Zi-Teng Yang et al.· Bioresource Technology· 0 citations
d-Pantothenic acid (D-PA) is an essential precursor of coenzyme A and the acyl carrier protein. Its biosynthesis requires abundant precursors and precise regulation of the multifunctional enzyme, ketopantoate reductase. Here, we engineered Corynebacterium glutamicum for enhanced D-PA production through metabolic engi...
Qing Yang, Bo Zhang, Liang-Gang Huang et al.· ACS Synthetic Biology· 0 citations
This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.
Qing Yang, Tao-Shun Zhou, Bo Zhang et al.· Biotechnology and Bioenginee...· 0 citations
Adenosine is a major bioactive nucleoside and quality marker in cordyceps-derived fungal products, but its efficient biosynthesis in Paecilomyces hepiali remains limited by insufficient strain performance and incomplete understanding of metabolic regulation. Here, we developed an integrated strategy combining protoplas...
Aiping Pang, Xin Li, Peng-Fei Zhang et al.· Biotechnology and Bioenginee...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
