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Liang-Liang Sun

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Open access Aug 2026

A Draft Map of E. coli Proteoforms

Top-down proteomics (TDP) enables direct characterization of intact proteoforms, providing protein-level insights into molecular diversity arising from post-translational modifications and sequence variations. Despite this advantage, proteome coverage in TDP remains limited relative to bottom-up proteomics (BUP). To ex...

Jorge A. Colón-Rosado, Fei Fang, Liang-Liang Sun · 0 citations
Open access Aug 2026

Proteoform Barcode: An Intuitive Visualization Framework for Top-Down Proteomics

Top-down proteomics (TDP) advances biomedical research by providing a bird’s-eye view of proteoforms in cells, tissues, and biofluids. Thousands of proteoforms can be characterized using well-established TDP technologies, and potential proteoform biomarkers of diseases have been discovered. However, there is a lack of...

Yifan Yue, Guangyao Gao, Fei Fang et al. · 0 citations

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