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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Lilach Sheiner

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Open access Sep 2026

Complexome profiling of mitochondria in the myzozoan parasite of oysters, Perkinsus marinus

Mitochondrial complexes, such as the mitochondrial electron transport chain (mETC), the F1Fo-ATP synthase, the mitochondrial ribosome and the Translocase of the Outer Membrane (TOM) complex are centrally important for mitochondrial function and cell survival. Recently, an unexpected diversity in the composition of thes...

Andrew E. Maclean, Orsola Iorillo, Drahomíra Faktorová et al. · 0 citations
Open access Sep 2026

Proteome-wide crosslinking mass spectrometry reveals novel components of essential complexes in Toxoplasma

A high-coverage crosslinking mass spectrometry framework is developed to map the proteome-wide interactome of the model apicomplexan parasite Toxoplasma gondii and identifies and validated previously unrecognized components of essential protein complexes, including a structurally distinct ATP synthase subcomplex contai...

S. Butterworth, Ashley L. Gin, Shikha Shikha et al. · 0 citations
Open access Jul 2026

Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and Persistence

It is shown that disruption of FAE remodels the parasite lipidome, impairs fitness under fatty acid-limiting conditions, and reduces virulence and chronic persistence in mice, identifying FAE as a key metabolic pathway underpinning adaptation and persistence during chronic infection.

Daniel Walsh, Leandro Tana-Hernandez, Yoshiki Yamaryo-Botté et al. · 0 citations

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