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Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and Persistence

Daniel Walsh Leandro Tana-Hernandez Yoshiki Yamaryo-Botté Saniya Crouch Ving-Yun Li Leandro Lemgruber David Smith Cyrille Y. Botté María E. Francia Lilach Sheiner

Jul 2026 · bioRxiv · 0 citations

Biology

TL;DR

It is shown that disruption of FAE remodels the parasite lipidome, impairs fitness under fatty acid-limiting conditions, and reduces virulence and chronic persistence in mice, identifying FAE as a key metabolic pathway underpinning adaptation and persistence during chronic infection.

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