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Author

Lin-Lin Zhang

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Open access Sep 2026

Development and validation of an interpretable machine learning model for predicting chemotherapy-induced neutropenia in small cell lung cancer: a web-based clinical decision support tool

Objective To develop and validate an interpretable machine learning model for predicting grade ≥3 chemotherapy-induced neutropenia (CIN) in patients with small cell lung cancer (SCLC), and to establish a web-based clinical decision support tool for individualized risk assessment. Methods We conducted a retrospective ob...

Jing-Yue Zhang, Si-Yu Lu, Chang Liu et al. · 0 citations
Open access Aug 2026

DNA Damage Response Alterations Stratify Response to ICI-Based Therapy in Advanced NSCLC with High PD-L1 Expression

Patients with multiple DNA damage response gene alterations showed distinct immune profiles, higher rates of durable clinical benefit, and longer progression-free survival, and these findings suggest that genomic DNA damage response alterations may help identify patients who are more likely to benefit from personalized...

Fang Hao, Lin-Lin Zhang, Dian-Sheng Zhong · 0 citations

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