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Author

Lin-Wei Yang

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Review Open access Sep 2026

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

Cellular selection has emerged as a powerful approach for high throughput de novo discovery of bioactive cyclic peptides (CPs). This strategy coexpresses genetically encoded CP libraries with the target of interest in cells and uses customizable selection systems to link desired CP activities to a selectable phenotype...

Lin-Wei Yang, Abhijit Behera, Hannah J. Meyers et al. · 0 citations
Aug 2026

A dual-function interleukin-1 receptor couples bacterial recognition to MyD88-dependent NF-κB activation during antibacterial immunity in shrimp.

A previously unrecognized dual-function mechanism of crustacean IL-1R is revealed, acting both as a pathogen-recognition receptor and as a signaling receptor that activated the MyD88-Dorsal pathway to orchestrate antibacterial immunity.

Si-You Huang, Wan-Li Lu, Yuxin Shi et al. · 0 citations
2026

Phage-Assisted Continuous Selection of Bioactive Cyclic Peptides.

A comprehensive protocol for applying phage-assisted continuous evolution (PACE) strategy to select CP inhibitors against aggregation-prone proteins of interest is provided.

Lin-Wei Yang, Tina Wang · 0 citations

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