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METHODS A literature search was conducted using ProQuest and PubMed, covering publications from August 2016 to August 2026. Older references were included as appropriate.
Organofluorides, including trifluoromethylthiolated compounds, play an important role in pharmaceuticals, agrochemicals and materials science. Although the synthesis of these organofluorides has been well studied, harsh conditions and specific substrates are usually involved, which limited the development of this fie...
Rather than treating MNs as a universal replacement for systemic delivery, this review position them as a route-specific platform whose clinical value will depend on rational cargodevice matching, standardized potency testing, and validation in translational models.
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