A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and “Fight or Flight” Responses
Highlights What are the main findings? A 7aa region in the proximal C-terminus is essential for embryonic development and the structural integrity of Cav1.2. Mutation of S1487 to alanine attenuates the increase in ICaL following β-adrenergic receptor stimulation in vitro and in vivo. What are the implications of the ma...
Cathy Jenkins, Henrietta Cserne Szappanos, A. Dyrda et al.
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