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Author

Lucile Plumet

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Open access Aug 2026

Training a phage to expand its host range: directed evolution against Staphylococcus aureus from diabetic foot infections

Both the potential and the limitations of phage training to expand therapeutic coverage are demonstrated and the need to integrate evolutionary approaches with physiologically relevant models to optimize phage therapy for chronic infections, such as DFIs is emphasized.

Lucile Plumet, Chloé Magnan, M. Morsli et al. · 0 citations
Aug 2026

Unraveling Resistance and Thresholds in Phage Therapy Using In Vitro Staphylococcus aureus experiments and Pharmacokinetic/Pharmacodynamic Models.

This study provides a quantitative in vitro framework for understanding the S. aureus and phage co-dynamics and resistance emergence and identified threshold phenomena offer insights into the experimental dose-response relationship and may guide future investigations.

Kévin Royet, Leslie Blazère, Emilie Helluin et al. · 0 citations

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