Aug 2026
PTX3 induces the expression of PD-L1 and promotes breast cancer immune escape.
It is demonstrated that PTX3 promotes immune evasion in breast cancer by upregulating PD-L1 by increasing the expression of the E3 ligase RNF216 and caused Beclin-1 degradation, which suppressed autophagy, thereby preventing autophagy-mediated PD-L1 degradation.
Li-Yuan Jing, Lun Jie, Jianxin Xu et al.
· Breast Cancer · 0 citations