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PTX3 induces the expression of PD-L1 and promotes breast cancer immune escape.

Li-Yuan Jing Lun Jie Jianxin Xu Zhengyu Jin Xing-Qian Liu Yu Wang Yuying Zhang Min Gao Mengchao Yu Hong-Wei Zhang Jing Fang
Aug 2026 · Breast Cancer · 0 citations · 37 references
Medicine

TL;DR

It is demonstrated that PTX3 promotes immune evasion in breast cancer by upregulating PD-L1 by increasing the expression of the E3 ligase RNF216 and caused Beclin-1 degradation, which suppressed autophagy, thereby preventing autophagy-mediated PD-L1 degradation.

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