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Open access Sep 2026

Changes in serum β‐synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome

There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood bi...

Alba Cervantes González, A. Morcillo-Nieto, Sara Serrano et al. · 0 citations
Open access Aug 2026

Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) constitute a clinico‐genetic‐neuropathological continuum with marked heterogeneity. Reliable in vivo biomarkers of the disease are lacking. Large, multimodal cohorts are needed to advance biomarker discovery and precision medicine.

Á. Carbayo, J. Turon-Sans, D. Alcolea et al. · 0 citations

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