Open access
Changes in serum β‐synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome
Alba Cervantes González
A. Morcillo-Nieto
Sara Serrano
B. Benejam
L. Videla
I. Barroeta
S. Fernández
L. del Hoyo Soriano
A. S. Hernandez
Lucía Maure-Blesa
L. Vaqué-Alcázar
J. Arranz
Í. Rodríguez-Baz
M. Aranha
Danna Perlaza
Laia Lidón
D. Alcolea
A. Bejanin
M. Carmona-Iragui
Juan Fortea
A. Lleó
M. Otto
P. Oeckl
O. Belbin
Medicine
Abstract
There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood biomarkers along the AD continuum.