Author

Michael R. Bruchas

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Sep 2026

Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.

It is indicated that chronic stress alters Pnoc and mRNA levels of Pnoc-expressing cells in a sex-selective and region-specific manner impacting reward structures, and that NOPR antagonism shows promising efficacy in increasing reward-related behaviors in rodents and humans.

D. Pizzagalli, Meghan E. Gallo, M. Treadway et al. · Molecular Psychiatry · 0 citations

Open access Aug 2026

Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action

It is found that glutamatergic axon terminals from the basolateral amygdala evoke striatal dynorphin release, resulting in feed-forward retrograde presynaptic GPCR inhibition to promote behavior, and subsequent GPCR activity for promoting goal-directed behavior.

Raajaram Gowrishankar, Madelyn M. Hjort, Abigail J. Elerding et al. · Cell · 1 citation