Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.

D. Pizzagalli Meghan E. Gallo M. Treadway Brian D. Kangas J. Breton Michael R. Bruchas A. Graybiel Emily Hueske Kevin G. Bath

Sep 2026 · Molecular Psychiatry · 0 citations · 66 references

Medicine

TL;DR

It is indicated that chronic stress alters Pnoc and mRNA levels of Pnoc-expressing cells in a sex-selective and region-specific manner impacting reward structures, and that NOPR antagonism shows promising efficacy in increasing reward-related behaviors in rodents and humans.

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