M. Çimentepe

Antibacterial, Anti-Inflammatory, and Wound-Healing Effects of Micromeria fruticosa Essential Oil-Loaded Nanoemulsion in MRSA-Infected Diabetic Wounds: In Vitro and In Vivo Evaluation

Background/Objectives: Diabetic foot ulcers infected with methicillin-resistant Staphylococcus aureus (MRSA) heal poorly and respond inadequately to conventional antibiotic therapy. This study developed a Micromeria fruticosa essential oil-loaded nanoemulsion (Mf-NE) as a topical treatment for such wounds. Methods: The...

Synthesis and Characterization of Silibinin-Loaded ZIF-8 Nanocomposites and Their Antibacterial Activity Against Escherichia coli: Insights into acrB, recA, and htpX Gene Expression

Background/Objectives: In this study, ZIF-8 and silibinin-loaded ZIF-8 nanostructures containing different concentrations of silibinin were successfully synthesized using a one-pot method and characterized by FT-IR, SEM, and EDX analyses. Methods: The antibacterial activities of the synthesized nanostructures were subs...

Sustainable Chitosan–PF127 Hydrogel Incorporating Waste Lemon Peel Hydrochar and Pistachio Resin for Antibacterial Activity and MRSA-Infected Wound Healing

It is demonstrated that the combination of waste-derived hydrochar and natural pistachio resin within a CS–PF127 matrix provides a sustainable and effective strategy for the treatment of MRSA-infected wounds, highlighting its potential as a next-generation antibacterial wound dressing.

Silybin-Loaded Chitosan–Gelatin Hydrogels as a Novel Strategy for MRSA-Infected Diabetic Foot Treatment: In Vitro, In Vivo, and In Silico Evidence

In vivo evaluation in an MRSA-infected diabetic foot wound model demonstrated accelerated wound closure and superior healing outcomes for both SB1 and SB2 compared with fusidic acid (Fucidin®) by day 12, suggesting that silybin-loaded CS–Gel hydrogels represent a promising therapeutic platform for the management of MRS...

Antimicrobial, antibiofilm, and virulence gene modulatory effects of supercritical CO₂ extracts of Thymbra spicata against clinical MRSA isolates.