Author

M. Giera

3 papers indexed here

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Open access Aug 2026

Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation

In multiple sclerosis (MS), the chronic, unresolved nature of neuroinflammation within the central nervous system (CNS) remains a major obstacle for effective therapeutic intervention. This challenge arises primarily due to an incomplete understanding of the dysregulated inflammatory and pro-resolving pathways underlyi...

J. Konings, Fleur Mingneau, Serhii Chornyi et al. · Acta Neuropathologica · 0 citations

Open access Aug 2026

From injury to degeneration: delayed lipid-mediated neurotoxicity in a human astrocyte traumatic brain injury in-a-dish model

Traumatic brain injury (TBI) is a major cause of long-term neurological disability, and repeated mild TBI (rmTBI) is increasingly linked to chronic neurodegeneration. Clinical evidence suggests that rmTBI creates a prolonged window of vulnerability to further injury. However, the astrocyte-intrinsic mechanisms that c...

Luise Schlotterose, Michel A. Struwe, A. Scheidig et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

Identification of cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile.

Glycosylation of bacterial surface proteins, such as flagellin (FliC), is important for their function and is often involved in virulence of pathogens. Glycans can be further modified by so-called postglycosylation modifications (PGMs), often resulting in exclusive molecular structures. In Clostridioides difficile, a u...

P. Hensbergen, Bob van Puffelen, Nina Musch et al. · Proceedings of the National... · 0 citations