Author

M. Kello

3 papers indexed here

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Open access Sep 2026

Lichens as a Source of Nematocidal Compounds: Identification of Sphaerophorin and Divaricatic Acid Active against Caenorhabditis elegans

Increasing helminth drug resistance necessitates novel anthelmintic agents. Lichens, historically used to treat parasitic infections, represent a promising natural resource. This study evaluated eight lichen extracts and 17 metabolites against the model organism Caenorhabditis elegans (wild-type strain N2). Extracts of...

Richard Frenák, Z. Vaneková, Simone Lager et al. · ACS Omega · 0 citations

Open access Sep 2026

A Novel Indole-Dihydroisoxazole Compound Activates Apoptotic, Mitochondrial and Autophagy-related Responses in Lymphoid and Myeloid Leukemia Cells.

Findings highlight the therapeutic potential of isoxazole-derived compounds, particularly DHI1, warranting further investigation in additional preclinical models and provide valuable insights into the molecular mechanisms underlying the antiproliferative effects of DHI1.

Monika Majirská, Zuzana Kudličková, M. Kello et al. · European Journal of Pharmaco... · 0 citations

Sep 2026

A novel dihydroisoxazole derivative DHI9 suppresses colorectal cancer cell survival by inducing oxidative stress, DNA damage, and mitochondrial apoptosis while targeting Akt and Wnt/β-catenin signalling.

Dihydroisoxazole derivative DHI9 modulated selected proteins involved in Wnt/β-catenin and Akt signalling pathways, apoptosis, and cell cycle regulation, and enhanced the cytotoxic activity of 5-fluorouracil, with predominantly synergistic interactions according to the Highest Single Agent model.

Simona Žiláková, Dominika Varcholova, Viktória Medvecová et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations