A novel dihydroisoxazole derivative DHI9 suppresses colorectal cancer cell survival by inducing oxidative stress, DNA damage, and mitochondrial apoptosis while targeting Akt and Wnt/β-catenin signalling.
Sep 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 65 references
Medicine
TL;DR
Dihydroisoxazole derivative DHI9 modulated selected proteins involved in Wnt/β-catenin and Akt signalling pathways, apoptosis, and cell cycle regulation, and enhanced the cytotoxic activity of 5-fluorouracil, with predominantly synergistic interactions according to the Highest Single Agent model.
In vivo validation in PC-3 xenograft mice confirmed that 11 M exerted robust tumor growth suppression with low systemic toxicity, accompanied by DNMT3A downregulation and MAPK pathway activation, substantiating its multi-target therapeutic mechanism.
The increasing global incidence of cancer and the recurrent development of resistance to standard treatments require a rapid development of innovative, multi-targeted chemotherapeutic medicines. This study focused on the strategic design and synthesis of a range of new cyanopyridine derivatives (1a,b-5a,b) targeting th...
Shimaa M. Alhamaky, Marwa S. A. Hassan, Eman M. Ahmed et al.· Bioorganic chemistry (Print)· 0 citations
ABSTRACT One of the most common prevalent forms of cancer in the world is oral squamous cell carcinoma (OSCC). In the present study, we explore the chemotherapeutic effect of Sclareol on human oral carcinoma KB cells in scientifically found that cellular and molecular alterations. The human oral carcinoma KB cell and A...
Anandhi Nallu, Suresh Kathiresan, Theerthu Azhamuthu et al.· Journal of biochemical and m...· 0 citations
Findings indicate that bioactive compounds from A. biennis can suppress colorectal cancer cell growth through apoptosis induction and consistent with inhibition of migration-related behavior, highlighting their potential for further investigation as anticancer agents.
F. Farahani, Batoul Khafaji, Fatemeh Bidgolian et al.· BMC Cancer· 0 citations
Lung cancer remains a major cause of death globally, responsible for a significant portion of all cancer-related deaths despite advancements in therapeutic modalities. Consequently, there is a great demand for new treatment strategies that can improve anti-cancer efficiency while minimizing toxicity
in vivo
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The findings of this study suggest that diosgenin may contribute to reducing 5-FU resistance by affecting ATR/CHK1-associated DNA damage response mechanisms, weakening DNA repair mechanisms, and suppressing drug efflux pumps.
Bita Azizzadeh, A. Mihanfar, M. Majidinia· Cancer Treatment and Researc...· 0 citations
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