Author

Viktória Medvecová

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Open access Sep 2026

Lichens as a Source of Nematocidal Compounds: Identification of Sphaerophorin and Divaricatic Acid Active against Caenorhabditis elegans

Increasing helminth drug resistance necessitates novel anthelmintic agents. Lichens, historically used to treat parasitic infections, represent a promising natural resource. This study evaluated eight lichen extracts and 17 metabolites against the model organism Caenorhabditis elegans (wild-type strain N2). Extracts of...

Richard Frenák, Z. Vaneková, Simone Lager et al. · ACS Omega · 0 citations

Sep 2026

A novel dihydroisoxazole derivative DHI9 suppresses colorectal cancer cell survival by inducing oxidative stress, DNA damage, and mitochondrial apoptosis while targeting Akt and Wnt/β-catenin signalling.

Dihydroisoxazole derivative DHI9 modulated selected proteins involved in Wnt/β-catenin and Akt signalling pathways, apoptosis, and cell cycle regulation, and enhanced the cytotoxic activity of 5-fluorouracil, with predominantly synergistic interactions according to the Highest Single Agent model.

Simona Žiláková, Dominika Varcholova, Viktória Medvecová et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations