Open access
Aug 2026
Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome
Down syndrome, caused by trisomy 21, is characterized by chronic interferon-associated inflammation and immune dysregulation, yet the contribution of human secondary lymphoid organs to shaping this immune landscape remains unclear. Using multimodal single-cell and spatial profiling of human tonsils, we identify extensi...
J. Dutto, Jeremías Bustos, Lucía Boffelli et al.
· bioRxiv · 0 citations