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This chapter presents a mechanistic framework for examining how neuromodulation may be leveraged to modulate microglial activity in neurodegenerative diseases, with the goal of positioning microglia as measurable and biologically grounded therapeutic targets.
The stimulation-induced decreases in phase-amplitude coupling were correlated with real-time improvement in bradykinesia and predicted by clinical factors, and could be predicted in task-specific pathways consisting of the primary motor cortex and the dorsal premotor cortex.
Spinal cord injury (SCI) induces neuronal loss and demyelination, leading to maladaptive neuronal circuits that drive persistent central neuropathic pain (PCNP). While pharmacological, psychological, and physiotherapeutic approaches have been applied, including whole-body vibration (WBV), synaptic-level mechanisms of W...
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