2026· Advances in Immunology· Vol 171, pp.
205-214
· 0 citations
Medicine
TL;DR
This chapter presents a mechanistic framework for examining how neuromodulation may be leveraged to modulate microglial activity in neurodegenerative diseases, with the goal of positioning microglia as measurable and biologically grounded therapeutic targets.
This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.
Jie Chen, Wangzheqi Zhang, Li-Zhou Song et al.· Clinical and Translational M...· 0 citations
Intervention strategies that shift from targeting peripheral immune and glial cells to regulating neuron-derived immunity are systematically integrated, thereby providing a new theoretical framework for overcoming current clinical limitations and identifying effective therapeutic targets for the prevention and treatmen...
Jie Bu, Xuan Nie, Haiting Luo et al.· Pharmacological Research· 0 citations
A microglial immunometabolic trajectory framework is proposed in which metabolic states are viewed as branching and potentially reversible determinants of cellular function rather than fixed stages of a universal disease pathway.
Qiao-Qiao Cui, Ke Zheng, Qi-Yun Liu et al.· Frontiers in Molecular Neuro...· 0 citations
This chapter focuses on the diversification of neurodegenerative CNS microglial states, the interaction of microglia with neurons, glial cells, adaptive immune cells, and the vasculature, and how this framework provides a basis for therapeutic strategies aimed at modulating, replacing, or reprogramming microglia in neu...
Hao Huang, E. Mass· Advances in Immunology· 0 citations
Neuroinflammation represents a common pathological mechanism underlying a wide range of central nervous system (CNS) disorders, encompassing neurodegenerative disorders (NDDs), ischemic stroke (IS), traumatic brain injury (TBI), and demyelinating diseases such as multiple sclerosis (MS). This process is initiated by th...
This work situates MiET formation within the broader microglial functional repertoire and focuses on how ET-dominant responses may compromise homeostatic or neuroprotective roles, expanding the conceptual framework for microglial pathogenicity and inviting future mechanistic and translational research.
Lipika Sha, Sushmita Jha· Advances in Immunology· 0 citations
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