Network biology uses gene correlations to characterize biological pathways. Linear Interpolation to Obtain Network Estimates for Single Samples (LIONESS) enables individualized gene networks, but the influence of methylation derived replication timing and tissue morphology on these networks remains unclear. We integrat...
Background The spatial organization of cellular lineages within the tumor microenvironment governs disease progression and therapeutic response, but multiplexed spatial profiling remains costly, technically complex, and tissue-destructive. Routine hematoxylin and eosin (H&E) histopathology is inexpensive and widely ava...
Usman Afzaal, Usama Sajjad, A. Akbar et al.· Research Square· 0 citations
Background: Five-year survival prediction from hematoxylin-and-eosin whole-slide images could support risk stratification, but the task is weakly supervised, and the tissue morphologies carrying prognostic information remain incompletely characterized. Methods: We conducted a retrospective secondary analysis using TCGA...
Hikmat Khan, M. Gurcan, Anil Parwani et al.· 0 citations
into basal-like and classical states is a critical prognostic determinant, yet clinical implementation remains limited by the cost and turnaround time of transcriptomic sequencing. 1 – 3 Although routine histopathology captures rich morphological features, deep learning models often lack a principled connection to gene...
Alejandro Leyva, Abdul Rehman Akbar, M. Niazi· Signal Transduction and Targ...· 0 citations
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