Author

M. Nishiyama-Jr

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Open access Aug 2026

Miltefosine regulates gene expression related to morphogenesis and zinc metabolism in Candida albicans and Candida tropicalis

ABSTRACT Candida albicans and Candida tropicalis are major hyphae-forming pathogens causing candidiasis. The rise of antifungal resistance underscores the need for new therapeutic strategies. Miltefosine (MFS), an alkylphosphocholine designated as an orphan drug for invasive candidiasis, has shown inhibitory, fungicida...

M. M. dos Santos, Vinícius de Morais Barroso, Sofia Prampero et al. · Microbiology spectrum · 0 citations

Open access Oct 2026

Multi-scale Transcriptional Characterization of HPV16 and HPV18 in Cervical Cancer: Host Pathway Alterations and Links With Viral Gene Expression Programs

High-risk HPV is central to cervical carcinogenesis, but whether individual genotypes drive distinct tumor biology or converge on a shared oncogenic state remains unclear. Profiling viral and host gene expression across two independent cohorts (n = 93; 76 HPV16, 17 HPV18), we show that HPV16-and HPV18-associated cervic...

Marcela Akemi Ishihara, Maiara M. Moro Valeriano, Noilson Oliveira et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Unraveling the Glycosylation Machinery of Bothrops jararaca Snake Through Multiomics and Structural In Silico Analyses

Multiomics and structural in silico analyses of publicly available experimental genomic, transcriptomic, and proteomic datasets are performed, combined with structural modeling, to investigate the glycosylation pathway of the medically important snake B. jararaca, suggesting that the glycosylation machinery is coupled...

Thales A. M. Fernandes, M. Nishiyama-Jr · International Journal of Mol... · 0 citations