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M. Pirovino

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Open access Aug 2026

A minimal model of stable autocatalytic RNA-replication through integration of replication, molecular regulation, and energy conversion

A minimal mathematical model of an autocatalytic RNA-world system in which replication, ATP/ADP-based energy conversion, and ATP-dependent allosteric regulation become dynamically coupled is developed, suggesting that stable RNA-based evolution required the progressive integration of information replication, molecular...

Bernard Conrad, Christian Iseli, M. Pirovino · 0 citations

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