A minimal mathematical model of an autocatalytic RNA-world system in which replication, ATP/ADP-based energy conversion, and ATP-dependent allosteric regulation become dynamically coupled is developed, suggesting that stable RNA-based evolution required the progressive integration of information replication, molecular reulation, and increasingly efficient metabolic energy conversion.
It is proposed that early replication and protein biosynthesis were inseparable functions performed by a single ancient RNA molecule: the riboreplisome, and this hypothesis addresses fundamental challenges facing RNA world, protein world, and RNA-protein co-evolution theories.
Alice Cleynen, Archa H. Fox, Nikolay E. Shirokikh· 0 citations
The RNA world hypothesis provides a compelling framework for the emergence of life, yet a fundamental gap remains between simple abiotic molecules and complex functional RNA polymers. Here, we propose the Functional Abiotic Metabolite Assembly hypothesis, in which simple prebiotically abundant molecules, particularly a...
P. Chakraborty, Cheng-Qian Yuan, Shon A. Levkovich et al.· Nature Communications· 0 citations
The structure of such a polymerase ribozyme bound to RNA substrates comprising the template, primer, and nucleoside triphosphate (NTP) analog is presented, revealing how directed evolution shaped flanking elements around a highly conserved catalytic core derived from the ancestral class I ligase ribozyme.
Timothy S. Strutzenberg, David P. Horning, W. Cochrane et al.· bioRxiv· 0 citations
The emergence of new viral diseases and viral drug resistance presents a critical challenge in human health. Recent structural and mechanistic studies have revealed remarkable parallels and structural similarities among viral dsDNA- and dsRNA-packaging motors, ATPases, ATP-binding cassette drug transporters (ABCs), a...
Margaret Bohmer, Justin Gnarra, Daniel W. Binzel et al.· Frontiers in RNA Research· 0 citations
The central dogma of molecular biology, which delineates the flow of genetic information from DNA to RNA to proteins, is fundamental to cellular identity and functionality. This process involves intricate steps of transcription, mRNA processing, translation, and protein processing, each of which has been studied extens...
Bo-Kai Zhu· Advances in Experimental Med...· 0 citations
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