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M. Sakaguchi

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#protein folding Sep 2026

Microsecond Barrier-Crossing Collapse in Cytochrome c Folding Revealed by Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy

The results reveal that the collapse exhibits two-state dynamics between structurally distributed ensembles, occurring on a time scale of tens of microseconds across all variants, indicating a global contraction of the whole protein structure with a substantial free energy barrier.

M. Sakaguchi, M. Yamanaka, Shun Hirota et al. · 0 citations

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