M. Scholle

The Dibasics of M13 Phage Display: Examining the Substrate Specificity of Escherichia coli Outer Membrane Proteases.

Findings indicate that phage propagation in Omptin-expressing bacteria leads to the loss of dibasic amino acid motifs from phage-displayed combinatorial peptide, protein, and antibody libraries, which suggests that the presence of dibasic residues in proteins and peptides displayed on bacteriophage M13 should necessita...