M. Shirasu-Hiza

Directed evolution of the Drosophila microbiome improves intestinal health and extends lifespan

A directed evolution outside of the host (ex vivo) and generated a Drosophila gut microbiome resistant to paraquat, a toxin that causes oxidative stress serves as a proof of principle that increasing the resistance of the microbiome to oxidative stress via directed ex vivo evolution could serve as a therapeutic strateg...