M. Shukry

Unraveling acetamiprid resistance in Aphis craccivora (Hemiptera: Aphididae): resistance risk assessment, fitness costs, cross-resistance, biochemical and molecular characterization, and in silico docking study

Enhancing the Oocyte Ultrastructure and Antioxidant Defence System of In Vitro Matured Buffalo Oocytes via Resveratrol Supplementation.

Despite buffalo's ability to thrive in challenging climates, the scarcity of superior germplasm remains a significant barrier to enhancing the global buffalo industry. Resveratrol (RE) is a potent antioxidant known to improve oocyte maturation and developmental competence in several mammalian species. Yet, its specific...

VASP attenuates lipopolysaccharide-induced renal injury via modulation of TLR4 signaling, inflammation and oxidative stress.

BACKGROUND Vasopressin (VASP), also known as antidiuretic hormone, is a peptide hormone that helps regulate water balance and vascular tone. Emerging evidence suggests it also modulates immune responses and circulatory dynamics. Lipopolysaccharide (LPS) is found in the cell membranes of Gram-negative bacteria. It activ...

Comparative Effects of Individual and Combined Plant-Derived Essential Oils Against the Asian Citrus Psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae)

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), is a destructive insect pest of citrus crop due to direct feeding damage and indirect role in transmitting Huanglongbing disease, which infects the citrus production globally. However, limited studies were carried out on the efficacy of natural...

Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats.

BACKGROUND Methotrexate (MTX) can induce "chemo-brain," but mechanisms remain incompletely defined. Ferroptosis has been implicated in MTX toxicity. We investigated whether Empagliflozin (EMPA) protects against MTX-induced neurotoxicity by modulating ferroptosis-related pathways. METHODS Male Sprague-Dawley rats (n =...

Hepatoprotective effects of carvacrol nano-phytosomes against lead toxicity: Restoration of tissue architecture via NF-κB/NLRP3 suppression and antioxidant enhancement.

Compared to crude CRV, CRV-PNPs provided significantly better protection against Pb-induced hepatotoxicity by restoring hematological indices and liver function, correcting dyslipidemia, and attenuating histopathological alterations.

Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis

It is demonstrated that NG and HP could protect ovarian granulosa cells from CIS-induced damage through dual regulation of the Nrf2/heme oxygenase-1 (HO-1) antioxidant and nuclear factor kappa B (NF-κB) inflammatory axis, highlighting their potential as adjuvant therapies to mitigate chemotherapy-induced ovarian toxici...

Recuperative efficacy of Amphora coffeaeformis-enriched diet on immunotoxicological, hematobiochemical alterations, oxidative stress, proinflammatory genes disorder, and histopathological changes caused by cypermethrin toxicity in Nile tilapia.

This work investigates the potential protective effects of the diatom Amphora coffeaeformis as a feed additive against the deleterious effects (primarily on immune organs) of cypermethrin (CYP) in Nile tilapia, Oreochromis niloticus, with respect to hematology, immune/antioxidant parameters, biochemical indices, proinf...