Author

M. Sigal

2 papers indexed here

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#protein folding Open access Sep 2026

A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

Ulcerative colitis (UC) is a chronic mucosal immune disorder in which 30-50% of patients fail biologic therapy, yet the full-thickness immune architecture of medically refractory disease and reliable tissue-level markers of treatment response remain undefined. Using 10x Visium HD spatial transcriptomics (16-...

Qing-Quan Bai, Run-Yang Li, Zheng-Jin Liu et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma.

Positive associations between RSPO3 expression and inflammation suggest that RSPO3 signaling contributes to shaping the immune microenvironment of human intestinal-type GC, a phenotype specific to intestinal-type GC.

Anne-Sophie Fischer, Alexander Arnold, Hilmar Berger et al. · Gastric Cancer · 0 citations