Catalytic Enantioselective Aziridination of Z-Disubstituted Alkenes with Aspartyl β-Turn-Based Dirhodium(II) Metallopeptides and Assessment of Catalyst Scaffold Versatility
We report an enantioselective aziridination of open-chain Z-disubstituted alkenes, enabled by a dirhodium(II) metallopeptide featuring finely tuned, β-turn-biased peptidyl ligands. This method affords cis-aziridines in up to 99:1 er and exhibits broad tolerance toward diverse aryl substitution patterns and peripheral f...