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Open access Aug 2026

Catalytic Enantioselective Aziridination of Z-Disubstituted Alkenes with Aspartyl β-Turn-Based Dirhodium(II) Metallopeptides and Assessment of Catalyst Scaffold Versatility

We report an enantioselective aziridination of open-chain Z-disubstituted alkenes, enabled by a dirhodium(II) metallopeptide featuring finely tuned, β-turn-biased peptidyl ligands. This method affords cis-aziridines in up to 99:1 er and exhibits broad tolerance toward diverse aryl substitution patterns and peripheral f...

Melissa Pighetti, Beck R. Miller, Annika K. Ehrlacher et al. · 0 citations
Open access Sep 2026

Direct Access to Chiral Piperidines by Enantioselective HAT-Initiated C(sp3)─H Oxidation.

Enantioselective C(sp3)─H functionalization reactions are appealing synthetic organic chemistry tools to streamline access to valuable chiral molecules from simple precursors. Chiral piperidines are ubiquitous motifs in pharmaceuticals and natural products, yet methods for their preparation from simple non-chiral precu...

Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call et al. · 0 citations

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