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Author

M. Sioud

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#protein folding Open access Oct 2026

N1-Methylpseudouridine-Modified mRNA-Transfected Dendritic Cells Enable Efficient Generation of Functional Tumor Antigen-Specific Cytotoxic T Lymphocytes

Efficient generation of tumor-specific cytotoxic T lymphocytes (CTLs) remains challenging. Although mRNA-based approaches enable the delivery and expression of diverse tumor-specific antigens, unmodified mRNA can trigger innate immune responses that suppress translation. Here, we investigated whether 1-methyl-pseudouri...

Tiffany Chor Kiu Ngan, M. Sioud · 0 citations
Review Open access Oct 2026

Molecular basis for developing tumor-targeted siRNAs for future immunotherapy.

By silencing genes involved in immune suppression, siRNAs can restore T cell activation and improve the efficacy of cancer vaccines and adoptive cell therapies, however, significant challenges remain.

M. Sioud · 0 citations

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