Author

M. Ursino

2 papers indexed here

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Preprint Sep 2026

PK/PD-integrated Bayesian platform design for phase II dose regimen optimization

A Bayesian phase II adaptive platform design for regimen optimization that integrates pharmacokinetic/pharmacodynamic (PK/PD) modelling into toxicity, efficacy, regimen selection and adaptation decisions is developed.

A. Vuorinen, A. Guillon, E. Comets et al. · 0 citations

Open access Oct 2026

Long term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm infants by Acetaminophen) Study (TREOCAPA-LT): protocol and statistical analysis plan

Introduction: The TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm infants by Acetaminophen) trial was a pan-European, multi-centre, phase II/III trial investigating the impact of prophylactic paracetamol (also known as acetaminophen) given during the first 5 days of life for children born before 29...

A. Morgan, J.-C. Rozé, M. Ursino et al. · medRxiv · 0 citations