#protein folding
Sep 2026
Microsecond Barrier-Crossing Collapse in Cytochrome c Folding Revealed by Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy
The results reveal that the collapse exhibits two-state dynamics between structurally distributed ensembles, occurring on a time scale of tens of microseconds across all variants, indicating a global contraction of the whole protein structure with a substantial free energy barrier.
M. Sakaguchi, M. Yamanaka, Shun Hirota et al.
· Journal of Physical Chemistr... · 0 citations