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Sep 2026

AMPKα1 activation enhances mitophagy to counteract hypoxia-induced neuronal apoptosis in cervical spondylotic myelopathy and facilitates functional recovery mediated by rosmarinic acid.

BACKGROUND Cervical spondylotic myelopathy (CSM) involves progressive neurological dysfunction often linked to mitochondrial impairment. Mitophagy, a selective autophagic process, is crucial for neuronal homeostasis; however, its role in CSM and the specific involvement of AMPK subunits in TFEB-mediated mitophagy remai...

Pei-Min Pu, Yu-Xiang Dai, Shi-Pian Li et al. · 0 citations
#protein folding Open access Sep 2026

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

ABSTRACT Spinal cord injury (SCI) is a devastating disorder of the central nervous system (CNS) leading to irreversible neurological deficits. Effective pharmacotherapy remains elusive, due to the restrictive blood‐spinal cord barrier (BSCB), underscoring the urgent need for targeted and efficient drug delivery strateg...

Yi-Xuan Wang, Bo Jin, Shi-Pian Li et al. · 0 citations

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