Author

M. Yigit

3 papers indexed here

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Open access Sep 2026

A CRISPR-Cas12a-Responsive DNA Tetrahedron

Functionalizing DNA nanostructures for stimuli-responsive reconfiguration has been a key area of development in DNA nanotechnology. Here, we demonstrate programmable control over the structural integrity of a tetrahedral DNA nanostructure using an external DNA stimulus that is modulated through an intermediate CRISPR...

Shubhajit Singha, M. Yigit, A. Chandrasekaran · Biochemistry · 0 citations

Open access Aug 2026

Invasive RNA Programs Optical Switching in DNA Nanoclusters for CRISPR Sensing

DNA-templated silver nanoclusters have regained attention due to recent advances in stability and tunable optical properties. Here, we report a highly regulated DNA-templated silver nanocluster (DFN2) that exhibits strong fluorescence at 561 nm and enables reversible, label-free fluorescence switching governed by nucle...

Reggie Gold, Y. Imtiaz, Vinod Morya et al. · Nano letters (Print) · 1 citation

Sep 2026

Split Activator Assembly via Aptamer Binding Enables CRISPR-Cas12a Activation With Non-Nucleic Acid Targets.

The programmability of CRISPR-Cas12a has enabled transformative advances in nucleic acid detection; however, extending its activation to non-nucleic-acid targets remains highly desirable. Here, we report a universal split-activator strategy that enables programmable Cas12a activation in response to a small molecule and...

R. J. Tharu, Y. Imtiaz, Shubhajit Singha et al. · Small Methods · 0 citations