M. Zaki

Organelle-Targeted Nanocarriers for Cancer Therapy: Design Principles, Intracellular Trafficking, and Translational Barriers in Precision Drug Delivery

Abstract The clinical translation of cancer nanomedicine remains constrained by inefficient intracellular delivery, poor subcellular specificity, and limited tumor accumulation, highlighting the need for more precise drug delivery strategies. Organelle-targeted nanocarriers have emerged as a promising platform for enha...

Water-Driven Multicomponent Reactions: A Sustainable Platform for Heterocycle Synthesis

Synthesis, spectroscopic and DFT investigation of a dual-fluorophore methylene blue-naphthalimide probe for selective Cu2+ ions sensing and HeLa cell imaging.

Cu2+ ions are essential trace elements in biological systems. Any imbalance in their level leads to serious neurodegenerative diseases like Wilson's disease, Parkinson's disease, and Alzheimer's disease. In addition, Cu2+ ion pollution from the environment can cause further health problems. Therefore, developing sensit...

Green Synthesis, Molecular Modelling, and ADME Evaluation of Functionalized Pyridine Derivatives as Potential SARS-CoV-2 Inhibitors

It is suggested that the synthesized pyridine scaffolds hold potential as lead candidates for further antiviral drug development.