TL;DR
It is suggested that the synthesized pyridine scaffolds hold potential as lead candidates for further antiviral drug development.
A novel and an efficient synthesis of a series of cyano-amide derivatives 3a-h was achieved via solvent-free reaction of benzylcyanide derivatives 1 with isocyanate derivatives 2 at room temperature. The produced components were structurally characterized by NMR spectroscopy multinuclear: 1 H and 13 C and e...
A sustainable and environmentally friendly approach for the synthesis of novel pyrimidine Schiff base derivatives through a multicomponent grinding reaction conducted at room temperature under solvent-free conditions is reported, suggesting that compound (3) may serve as a promising lead candidate for breast cancer the...
The design and synthesis of ten disubstituted tetrazole derivatives (5a–5j) via a one-pot, four-component Ugi-azide reaction (UGI-4CR) employing 2-(4-chloro-2-formylphenoxy)acetonitrile, variously substituted primary aromatic amines, trimethylsilyl azide, and tert-butyl isocyanide in anhydrous methanol at ambient tempe...
Abstract This study focuses on the design, green synthesis, and biological evaluation of a series of novel pyrano-bis-coumarin analogs as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. A new saccharin-based ionic liquid, tris(2-hydroxyethyl)ammonium 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)...
The weakly coordinating ketone group-directed C–H functionalizations of chromones, flavones, 1,4-naphthoquinones, (thio)xanthones, and acridones with ethenesulfonyl fluoride under rhodium(III) or ruthenium(II) catalysis are described. These protocols efficiently provide a range of chromone-based scaffolds and xanthone...
Various 2-fluorophenyl-adamantane analogs were studied to examine the potential for developing anticancer agents. This approach combined the synthesis of novel analogs spanning several structural variations, followed by in vitro cytotoxicity assessment, then computational studies utilizing network pharmacology, molecul...
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