Author

Manar A. Nader

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Sep 2026

Empagliflozin attenuates PTZ-induced neurotoxicity and enhances the protective effects of levetiracetam: associations with NRF2/GPX4 and AMPK/ULK1/ LC3-II signaling.

PURPOSE To investigate the antiseizure and neuroprotective effects of empagliflozin (EMPA), administered alone or in combination with levetiracetam (LEV), in pentylenetetrazole (PTZ)-induced epilepsy model in rats. METHODS A modified window-PTZ kindling model was used to investigate associated biochemical and molecul...

A. Madkour, Mahmoud Elshal, Rania R. Abdelaziz et al. · Neurotoxicology · 0 citations

Open access Aug 2026

Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations

Findings demonstrate associations between carvedilol treatment and multiple pathological processes during PTZ-induced kindling, but do not establish direct pathway-specific causality.

Ahmed H. Madkour, Rania R. Abdelaziz, Manar A. Nader et al. · Scientific Reports · 0 citations

Jul 2026

Mangiferin mitigates tacrolimus-induced nephrotoxicity in rats via modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Results indicate that mangiferin confers nephroprotection against TAC-induced renal injury that is highly associated with the modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Naif S. Alharbi, Omnia Nour, M. Makled et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations