Mangiferin mitigates tacrolimus-induced nephrotoxicity in rats via modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Naif S. Alharbi Omnia Nour M. Makled Manar A. Nader

Jul 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 37 references

Medicine

TL;DR

Results indicate that mangiferin confers nephroprotection against TAC-induced renal injury that is highly associated with the modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

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