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Author

Omnia Nour

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Open access Oct 2026

Carbocisteine Confers Renoprotection in Streptozotocin-Induced Diabetic Nephropathy Through Sirt-1/Nrf-2-Dependent Inhibition of NLRP3 Inflammasome Activation.

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, largely driven by oxidative stress and inflammation. This study evaluated the protective role of carbocisteine, a mucolytic with antioxidant and anti-inflammatory properties, against streptozotocin (STZ)-induced DN in rats. Male Sprague-Dawley rat...

Omnia A. Nour, Mahmoud M. Samaha · 0 citations
Jul 2026

Mangiferin mitigates tacrolimus-induced nephrotoxicity in rats via modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Results indicate that mangiferin confers nephroprotection against TAC-induced renal injury that is highly associated with the modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Naif S. Alharbi, Omnia Nour, M. Makled et al. · 0 citations

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