Results indicate that mangiferin confers nephroprotection against TAC-induced renal injury that is highly associated with the modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.
Naif S. Alharbi, Omnia Nour, M. Makled et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
The protective mechanism involves anti-oxidant enhancement and inhibition of oxidative stress-induced inflammation and apoptosis, supporting the therapeutic potential of HSP in managing phthalate-related renal injury.
Tuba Karaarslan, B. Yıldırım, F. Yildirim et al.· Iranian Journal of Basic Med...· 0 citations
It is demonstrated that radiation-synthesized gallotannin hydrogel (GTH) exerts nephroprotective effects against ATO-induced nephrotoxicity, driven by antioxidant, anti-inflammatory, and anti-apoptotic mechanisms mediated via modulation of the miR-223/TXNIP axis.
Omayma A. R. Abo-Zaid, Mostafa A. Farrag, Aya S. R. Shaaban et al.· Biological Trace Element Res...· 0 citations
The antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2-pathway-modulating properties of quinic acid markedly attenuate cisplatin-induced acute kidney injury in rats and its impact on the associated oxidative, inflammatory, apoptotic, and Nrf2/HO-1/NQO1 pathways.
Mehdi Goudarzi, Z. Lamoochi, Susan Sabbagh et al.· Immunopharmacology and immun...· 2 citations
In this exploratory model, remogliflozin was associated with attenuation of TAA-induced renal injury and modulation of related biomarkers, and warrants further preclinical investigation in TAA-associated renal injury.
Marwa M. Qadri, D. Almarghalani, Abdulaziz Alarifi et al.· Toxicology Mechanisms and Me...· 1 citation
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