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Author

İsmail Bolat

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Oct 2026

Investigation of molecular effects of beta caryophyllene in cadmium-induced nephrotoxicity model in rats: in silico and in vivo studies.

BACKGROUND Cadmium is one of the toxic heavy metals that accumulate in the kidneys, and it can cause kidney damage by triggering oxidative stress, ER stress, inflammation, and apoptosis. β-caryophyllene (BCP) is a volatile ingredient found in various spice essential oils, known for its anti-inflammatory and strong oxyg...

Y. Sağlam, Betül Orhan, Burak Çınar et al. · 0 citations
Sep 2026

CUMYL-4CN-BINACA exposure is associated with oxidative stress, ER stress-related responses, apoptosis, and altered KIM-1, NGAL, and Nephrin expression in rat kidney.

Overall, C-4CN-B caused dose-dependent, multifactorial kidney injury through concurrent activation of oxidative, inflammatory, ER stress, and apoptotic pathways.

Esra Aktas Senocak, Ozkan Aksakal, Cihan Gür et al. · 0 citations
Aug 2026

Rosmarinic Acid Attenuates Isoniazid-Induced Neurotoxicity by Restoring Mitochondrial Dynamics and Suppressing Oxidative Stress, Ferroptosis, Neuroinflammation, and Apoptosis.

It is demonstrated that rosmarinic acid exerts potent neuroprotective effects against INH-induced brain injury by simultaneously targeting oxidative stress, mitochondrial dysfunction, iron dyshomeostasis, neuroinflammation, ferroptosis, and apoptosis.

Merve Bolat, Tuba Karaarslan, S. Tekin et al. · 0 citations
Jul 2026

Protective Effects of p-Coumaric Acid Against Lead-Induced Hepatic Oxidative Stress, Inflammation, and Apoptosis: Integrated Molecular and Machine Learning-Based Analysis.

Overall, PCA alleviates Pb-induced hepatotoxicity by restoring antioxidant defenses, suppressing inflammatory signalling, and inhibiting mitochondrial apoptotic pathways.

I. Bozkurt, Yeliz Demir, Tuba Karaarslan et al. · 1 citation
Aug 2026

Morin attenuates vancomycin-induced nephrotoxicity via Nrf-2/HO-1, SIRT1/PGC1α and AKT/FOXO1A pathways

Morin (MOR) treatment significantly ameliorated VCM-induced renal injury by reducing oxidative injury, restoring endogenous defense systems, attenuating inflammatory responses, suppressing apoptosis, and markedly improving histopathological lesions.

S. Tekin, Merve Bolat, Burak Batuhan Laçin et al. · 0 citations
Aug 2026

p-Coumaric Acid Attenuates Lead Acetate-induced Neurotoxicity in Rats by Improving Behavioral Dysfunction and Suppressing Oxidative Stress, Neuroinflammation, Apoptosis, and Plasticity-related Molecular Alterations.

It is suggested that p-coumaric acid exerts neuroprotective effects against PbAc-induced brain injury by attenuating oxidative stress, neuroinflammation, and apoptosis while supporting neuronal plasticity.

Tuba Karaarslan, Merve Bolat, İsmail Bolat et al. · 0 citations

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