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Author

Marissa Zintel

2 papers indexed here

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#protein folding Open access Sep 2026

Active learning enables evolutionary discovery and characterization of fungal transcriptional activators

A hybrid framework that leverages high-throughput molecular assays and active learning to quantify biological properties across evolutionary space and provides a general strategy for building predictive models that better capture the diversity of natural sequence-to-function relationships is presented.

Lucas M. Waldburger, Hunter M. Nisonoff, Marissa A. Zintel et al. · 0 citations
Review Open access Aug 2026

Interpretable biophysical neural networks of transcriptional activation domains separate roles of protein abundance and coactivator binding.

Deep neural networks have improved many difficult prediction tasks in biology, but it remains challenging to interpret these networks and learn the molecular mechanisms. Here, we address interpretation challenges by building biophysical neural networks for predicting activation domains, the regions within transcription...

Claire LeBlanc, Pooja Agarwal, Jack E. Demaray et al. · 0 citations

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