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Mark D. Knappenberger

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#protein folding Open access Sep 2026

Engineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation

Self-assembling mRNA origami (mRNA-OG), a class of unimolecular RNA nanostructures that encode protein-coding sequences within higher-order, programmable, and compact nucleic acid architectures, is developed and established as a new design parameter for mRNA therapeutics that can affect its functionality, delivery prop...

Mark D. Knappenberger, S. J. Henry, Archana Kikla et al. · 0 citations

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