Author

Mary Harper

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#protein folding Open access Oct 2026

SPRIZ (CCDC127) protein conserved in deuterostome animals is a rigid OMM–IMM tether that locally sets mitochondrial IMS volume

The double-membrane nature of mitochondria generates an intermembrane volume through which ions, reactive oxygen species, and metabolites must flux to reach the matrix or cytosol, but whether this volume is a genetically specified structure remains unknown. We identify SPRIZ (spatial regulator of the intermembrane zone...

Raman Shulinski, Roman Loban, Danny Farhat et al. · Science Advances · 0 citations

Open access Sep 2026

AMPKα regulates glycolytic reprogramming to sustain NK cell proliferation and effector function

Natural killer (NK) cells are critical innate lymphocytes that mediate early anti-viral immunity through cytotoxicity and cytokine production. Activation of NK cells require metabolic reprogramming to sustain proliferation and effector functions; however, the molecular regulators coordinating this process remain inco...

A. Khan, Jannat Pervin, Safa Ghaziasgar et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women

RYGB improves systemic metabolic health and induces sustained skeletal muscle bioenergetic reprogramming characterised by enhanced expression of genes involved in myogenesis and protein translation, but decreased expression of genes involved in mitochondrial metabolism, which may reflect improved mitochondrial quality...

Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy et al. · EBioMedicine · 0 citations