Author

Md Mahbub Hasan

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Open access Aug 2026

Targeting EZH2 Oncogenic Splicing: Decoding the Regulatory Network and Antisense Correction

This study instigated a gene-specific targeted strategy by unlocking the regulatory network, and designed antisense oligonucleotides (ASOs) targeting important regulatory sites, demonstrating that ASO pharmacology is an actionable strategy for clinical development, challenging the existing paradigms in SF-mutated cancers.

Md Rafikul Islam, Preeti Nagar, Naomi McNaughton et al. · Genes & Development · 0 citations

Open access Jul 2026

CRISPR-mediated Correction of Oncogenic AS-NMD in Splicing Factor Mutant Cancer

The CRISPR strategy shows compelling evidence as a therapeutic approach targeting PE in cancer and other human diseases as well as the preferential advantages of CRISPR over the antisense technology recently developed targeting the PE of EZH2.

Preeti Nagar, Md Rafikul Islam, Nirjhor Anuvob Rahman et al. · bioRxiv · 0 citations